When the radio buttons below are expanded, it should still be easy for the user to know which button toggles what.

The leading Horse is:
white red black green
The second Horse is:
white
red
black
green

When the checkbox buttons below are expanded, it should still be easy for the user to tell which button toggles what.

grand piano
reed and pipe organ
glockenspiel
bass guitar
double speed guitar
two slightly distorted guitars